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Uncertainties: Which alliances and partnership will hold, which one will fail, which ones will emerge, for how long? Will the Syrian peace conference occur and will it be successful, at which cost and with which geo-strategic impact? Is the European crisis over or not at all? Will Europeans continue to withstand the pressure, and for how long, and what will be next? Will the mammoth monetary experiment endeavoured by Japan be lethal or was it the right daring move? And what if the global financial and economic crisis was not at all over? Is climate change enhancing the likelihood of mega-tornadoes or not? How will the world face the various environmental pressures and the unintended consequences of the remedies pushed forward? Those rising and spreading uncertainties could show that we are now fully moving on a path fraught with multiple systemic shifts., with more dangers and threats, but also with more space for human liberty, if we are wise enough to take the measure of the challenges ahead.